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1. Cytochrome p450 enzymes are involved in biotransformation of drugs. CytP450 is present in –
2. In sickle cell anemia, glutamic acid is replaced by valine at 6th position. This mutation is defective in which structural organization of protein.
3. Catecholamines are synthesised from –
4. Monosaccharide derived from hydrolysis of milk sugar is-
5. All of the following compounds act as coenzyme except-
6. Which of the following statement about the glycogen metabolism is incorrect?
7. Co-factor for the free radical scavenging enzyme glutathione peroxidase is-
8. Hormones mediated by cAMP as second messenger are all except-
9. The lipoprotein which is synthesized in the intestinal mucosa, containing high concentration of triacylglycerol and apo B48 protein, and transports dietary lipids to extrahepatic tissue is-
10. Ketone bodies are produced from the acetyl CoA. Identify the correct statement about ketone bodies.
11. 75- year-old farmer visited general practitioner with weakness, diarrhoea, decreased vision, and purulent discharge from eyes. On examination, there were subcutaneous haemorrhage in the arms and legs. Eyes showed marked inflammation and dilatation of conjunctiva vessels and margins of eyelid, fissure at the angle of the mouth, tongue was sore and swollen. Deep tendon reflexes were diminished. Which vitamin deficiency causes changes in the eye?
12. Nonsteroidal anti-inflammatory drug (NSAID) aspirin inhibits which enzyme?
13. Identify the compound X in the reaction shown below. The deficiency of it leads to folate trap and homocystinuria.
14. In which compartment does the complete oxidation of acetyl Co A occur as shown in 2nd reaction, indicated by red arrow?
15. What is the name of the metabolic pathway indicated by red arrow?
16. Which of the mineral is required for the oxidative phosphorylation?
17. All of the following are uncouplers of oxidative phosphorylation except-
18. Post Translational modification of protein catalysed by vitamin K-
19. All the steroid hormones are derived from –
20. Copper containing enzymes are all except-
21. Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction was conducted. 441 women received vitamin D of 4400 IU/day. Mean age at enrolment was 27 years and the SD was 2.1. Calculate the Confidence interval of age?
22. In a multicenter, randomized, noninferiority trial, they compared two threshold values for treatment of asymptomatic moderate hypoglycemia. Mean ± SEM of threshold value of glucose in lower threshold group was 61±0.5 mg/dl. What is the confidence interval of glucose?
23. A 34-Year-Old Woman with severe Hyperglycemia was evaluated for its cause. During frequent visits, glucose was measured. Following were the recordings: 330, 331, 332, 331, 331mg/dl. What was the mean glucose?
24. A randomized experiment was done in pregnant women by randomly assigning each participant either to walk for half an hour three times a week or to sit quietly reading a book for half an hour three times a week. At the end of a year the change in participants’ blood pressure over the year was measured, and the change was compared for the two groups. This is a randomized experiment rather than an observational study because
25. Which one of the following variables is not categorical?
26. Which one of these statistics is unaffected by outliers?
27. A list of 5 pulse rates is: 70, 64, 80, 74, 92. What is the median for this list?
28. In a study the Iron levels were estimated. They were 100,100,99,101,100. Which among the following statement is true?
29. Which of the following statement is correct if a characteristic is normally distributed in a population?
30. Which of the following describes the observation that occurs with the greatest frequency?
31. Which of the following statement is correct regarding statistical distribution?
32. Which of the following is true regarding the standard deviation?
33. Which of the following is true if a characteristic is normally distributed in a population?
34. Which of the following is true regarding the standard deviation of a group?
35. A report of a clinical trial of a new post-operative analgesic states, “In a comparison between the new drug and a placebo, a higher proportion of patients taking the new drug obtained relief from pain (p <0.05)”. In consequence, which of the following statements is correct?
36. A diagnostic test has a sensitivity of 90% and a specificity of 95%. Which of the following statements is likely to be true in this case?
37. In a clinical trial of a new drug treatment for inflammatory bowel disease, the following results are obtained: 46 patients improved with new drug, 14 did not improve with new drug; 34 patients improved with placebo, 26 patients did not improve with placebo. Which of the following statement is true concerning this data?
38. Which of the following is not a continuous variable?
39. Which of the following is a standard method of reporting the results in a case control study?
40. Which of the following is true in significance testing?
41. A cohort study suggests a statistical link between drinking a specific local herbal tea and the development of oesophageal cancer. Which of the following would suggest that the link is causative?
42. Which of the following is true about normal distribution?
43. What is true regarding the confidence interval?
44. In comparing confidence intervals with P values, which of the following statements is correct?
44. In a double-blind placebo control clinical trial, which of the following statements is correct?
46. Which of the following is true when evaluating a report of a clinical trial?
47. A random selection of 1,200 adults agrees to participate in a study of the possible effects of drug X. They are followed prospectively for a period of five years to see if there is an association between the incidence of cataract and the use of drug X. What type of study is this?
48. Which of the following is not true concerning the use of a placebo in a clinical trial?
49. In a diagnostic accuracy study to determine thrombosis, sensitivity reported was 95% and specificity was 90%. A cross sectional study revealed that the prevalence of thrombotic disease in pregnancy in local population was 10%. What is the positive predictive value of the test?
50. In a diagnostic accuracy study to determine thrombosis, sensitivity reported was 95% and specificity was 90%. A cross sectional study revealed that the prevalence of thrombotic disease in pregnancy in local population was 10%. What is the negative predictive value of the test?
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